Overseeing them all is Dr. Derek Shepherd is the flirtatious but very capable surgeon who shares a forbidden but undeniable sexual attraction with Meredith. Meredith worries about DeLuca operating alone with Richard. Meredith is seemingly distracted and struggles to stay focused, and Maggie finds herself the keeper of a big secret while Amelia and Owen try to figure out their relationship. Meanwhile, Richard urges Meredith to visit her father, Thatcher, before his time is up. Alex and Jo are stuck at home and decide to make the best of it by having a second honeymoon, while Meredith confronts Richard about getting his life back on track.
Jackson and Richard deal with a gender non-binary patient. Meanwhile, Bailey and Ben have to talk to Tuck about dating. . Meanwhile, when working with a family seeking asylum, Meredith makes a call that could jeopardize her career. Meredith bonds with a patient while Jackson struggles with the meaning behind recent experiences; and after making a life-changing decision, Jo forms an unexpected alliance. Meanwhile, Jo and Alex's honeymoon doesn't go exactly as planned.
Jo has a hard time at work, and Owen tries therapy. Meanwhile, Teddy tries to tell Owen that she is pregnant but they get sidetracked, and Jo encourages Link to pursue one of the doctors. Real life only comes in shades of grey. Alex and DeLuca butt heads over an 11-year-old patient who tries to sabotage her own surgery. Meanwhile, Teddy has a pregnancy scare that brings Owen and Koracick to odds. The five interns struggle to form friendships in this most stressful and competitive atmosphere.
Meanwhile, Maggie tries to reach Teddy after bearing the burden of her secret becomes overwhelming as she struggles with issues in her own personal life. Meanwhile, Helen pays Alex and Jo a surprise visit. Meanwhile, Betty drops a bomb on Owen and Amelia. Meanwhile, Deluca steps up in the O. Meanwhile, one of the nurses is 28 weeks pregnant and collapses at the hospital while talking to Richard. Sometimes she cares a little too deeply about her patients.
And Alex Karev, the intern the other interns love to have, masks his working class roots with arrogance and ambition. Cristina is highly competitive and driven, but lacks tact when it comes to bedside manner. Meanwhile, Teddy and Owen work together on a married couple who is expecting, and Amelia attends a conference for alternative pain relief. Richard shares unexpected news with Meredith about her father, Thatcher. Meanwhile, Maggie reveals details about her personal life that cause a public stir, and Levi struggles with whether or not to tell his family about Nico. Meredith is a first year surgical intern at Seattle Grace Hospital, the toughest surgical residency program west of Harvard. .
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